Exploratory focus


Research and scientific education in bioprocess engineering are the main focus within the Institute of Bioengineering of the Martin-Luther-University. The Center of Bioprocess Engineering aims in developing advanced methods for transferring scientific results obtained in biotechnology, biochemistry and microbiology into economically rewarding production processes.
LabCam
LabCam

Scientific work in the centre concentrates on

(i) Process optimization and control
In optimization the objective is to derive process operation procedures that allow for a robust production of the desired products within safe limits.
Control is employed to make sure that the bioproduction process will follow the predefined paths even in the case of severe disturbances.

(ii) Bioprocess and bioreactor development
In bioprocess and bioreactor development, several hardware and software developments are performed to increase the performance of the reactors. This includes measurement techniques, fluid dynamic improvements and enhancements of the oxygen supply by means of new agitation systems.

In contracts with many international as well as domestic companies, expertise was gathered from beer fermentation, yeast production, many different antibiotics, and quite a number of recombinant therapeutic proteins produced with microbial or animal cell cultures.

The Center of Bioprocess Engineering offers supporting industrial companies in developing new processes and improving already running production processes, particularly in the field of recombinant therapeutic proteins.

Current publications:
 
Aufzählung Jenzsch, M., Simutis, R., Lübbert, A. (2005)
How to cope with FDA's PAT-initiative with respect to fermentation process monitoring and control 
J. Biotechnol., 118(1), Suppl.1, 49-50
 
 
Aufzählung Jenzsch, M., Lange., M., Bär, J., Rahfeld, J.U., Lübbert, A. (2004)
Bioreactor retrofitting to avoid aeration with oxygen in Pichia pastoris cultivation processes for recombinant protein production
Chemical Engineering Research and Design, 82(A9), 1144-1152
 
Aufzählung Jenzsch, M., Simutis, R., Lübbert, A. (2004)
Application of Model Predictive to Cultivation Processes for Protein Production with Genetically Modified Bacteria
Computer Application in Biotechnology 9th International Symposium (CAB9), Nancy, France
 
Aufzählung Jenzsch, M., Simutis, R., Lübbert, A. (2004)
Knowledge or Model-Based Control of the Specific Growth Rate in Fed-Batch Cultivations for Recombinant Protein Production
BATCHPRO-Symposium, Poros, Greece, 81-88
 
Aufzählung Levisauskas, D., Galvanauskas, V., Henrich, S., Wilhelm, K., Volk, N., Lübbert, A. (2003)
Model-Based Optimization of Viral Capsid Protein Production in Fed-Batch Culture of recombinant Escherichia coli
Bioprocess and Biosystems Engineering, 25, 255-262
 
Aufzählung Lübbert, A., Bay-Jorgensen, S. (2001)
Bioreactor performance: a more scientific approach for practice
J. Biotechnol., 85, 187-212
 

Poster-Download:


ECB12, Kopenhagen, Denmark (2005)
M. Jenzsch, R. Simutis, A. Lübbert
How to cope with FDA’s PAT-Initiative with Respect to Fermentation Process Monitoring and Control

BioPerspectives, Wiesbaden, Germany (2005)
M. Jenzsch, R. Simutis, A. Lübbert
Experiences with Monitoring and Control in Recombinant Protein Production

ESBES 5, Stuttgart, Germany (2004)
M. Jenzsch, R. Simutis, A. Lübbert
Model-Supported Control of Recombinant Production Fermenters: Pros and Cons of Different Approaches

CAB 9, Nancy, France (2004)
M. Jenzsch, R. Simutis, A. Lübbert
Application of Model Predictive Control to Cultivation Processes for Protein Production with Genetically Modified Bacteria
Download als ZIP-Datei (1036 KB)

BioPerspectives, Wiesbaden, Germany (2004)
M. Jenzsch, R. Simutis, A. Lübbert
Generetic Model Control of the Specific Growth Rate in a Recombinant Protein Production Process with Escherichia coli
Download als ZIP-Datei (825 KB)

BioPerspectives, Wiesbaden, Germany (2004)
S. Laue, M. Beck, A. Frings, A. Anton, A. Lübbert
Optimierung der Induktorkonzentration für die Produktion eines rekombinanten Inclusion body Proteins mit Escherichia coli
Download als ZIP-Datei (113 KB)